Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography

The lipid A biosynthesis pathway is essential in Pseudomonas aeruginosa. LpxA and LpxD are the first and third enzymes in this pathway respectively, and are regarded as promising antibiotic targets. The unique structural similarities between these two enzymes make them suitable targets for dual-bind...

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Publicado no:Sci Rep
Main Authors: Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820557/
https://ncbi.nlm.nih.gov/pubmed/31664082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51844-z
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