Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography

The lipid A biosynthesis pathway is essential in Pseudomonas aeruginosa. LpxA and LpxD are the first and third enzymes in this pathway respectively, and are regarded as promising antibiotic targets. The unique structural similarities between these two enzymes make them suitable targets for dual-bind...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Kroeck, Kyle G., Sacco, Michael D., Smith, Emmanuel W., Zhang, Xiujun, Shoun, Daniel, Akhtar, Afroza, Darch, Sophie E., Cohen, Frederick, Andrews, Logan D., Knox, John E., Chen, Yu
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820557/
https://ncbi.nlm.nih.gov/pubmed/31664082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51844-z
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