hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay

In the last decade, Nerve Growth Factor (NGF)-based clinical approaches have lacked specific and efficient Tyrosine Kinase A (TrkA) agonists for brain delivery. Nowadays, the characterization of novel small peptidomimetic is taking centre stage in preclinical studies, in order to overcome the main s...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Triaca, Viviana, Fico, Elena, Sposato, Valentina, Caioli, Silvia, Ciotti, Maria Teresa, Zona, Cristina, Mercanti, Delio, La Mendola, Diego, Satriano, Cristina, Rizzarelli, Enrico, Tirassa, Paola, Calissano, Pietro
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072391/
https://ncbi.nlm.nih.gov/pubmed/32024191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10020216
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