The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor

The nerve growth factor (NGF) N-terminus peptide, NGF(1–14), and its acetylated form, Ac-NGF(1–14), were investigated to scrutinize the ability of this neurotrophin domain to mimic the whole protein. Theoretical calculations demonstrated that non-covalent forces assist the molecular recognition of T...

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Détails bibliographiques
Publié dans:Front Neurosci
Auteurs principaux: Pandini, Giuseppe, Satriano, Cristina, Pietropaolo, Adriana, Gianì, Fiorenza, Travaglia, Alessio, La Mendola, Diego, Nicoletti, Vincenzo G., Rizzarelli, Enrico
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2016
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5201159/
https://ncbi.nlm.nih.gov/pubmed/28090201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00569
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