Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs

Terminal oligopyrimidine (TOP) motifs are sequences at the 5′ ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway. They are commonly regarded as discrete elements that reside on ∼100 mRNAs that mostly encode translation factors. However, the fu...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Philippe, Lucas, van den Elzen, Antonia M. G., Watson, Maegan J., Thoreen, Carson C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071917/
https://ncbi.nlm.nih.gov/pubmed/32094190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912864117
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