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Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs

Terminal oligopyrimidine (TOP) motifs are sequences at the 5′ ends of mRNAs that link their translation to the mTOR Complex 1 (mTORC1) nutrient-sensing signaling pathway. They are commonly regarded as discrete elements that reside on ∼100 mRNAs that mostly encode translation factors. However, the fu...

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Philippe, Lucas, van den Elzen, Antonia M. G., Watson, Maegan J., Thoreen, Carson C.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071917/
https://ncbi.nlm.nih.gov/pubmed/32094190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912864117
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