Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis

Developing lymphocytes diversify their antigen receptor (AgR) loci by variable (diversity) joining (V[D]J) recombination. Here, using the micrococcal nuclease (MNase)-based chromatin accessibility (MACC) assay with low-cell count input, we profile both small-scale (kilobase) and large-scale (megabas...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Lion, Mattia, Muhire, Brejnev, Namiki, Yuka, Tolstorukov, Michael Y., Oettinger, Marjorie A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071903/
https://ncbi.nlm.nih.gov/pubmed/32098847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914923117
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