Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has not been determined. Here,...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Goel, Rishi R., Wang, Xinghao, O’Neil, Liam J., Nakabo, Shuichiro, Hasneen, Kowser, Gupta, Sarthak, Wigerblad, Gustaf, Blanco, Luz P., Kopp, Jeffrey B., Morasso, Maria I., Kotenko, Sergei V., Yu, Zu-Xi, Carmona-Rivera, Carmelo, Kaplan, Mariana J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2020
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071891/
https://ncbi.nlm.nih.gov/pubmed/32094169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1916897117
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