Transcriptomic, epigenetic, and functional analyses implicate neutrophil diversity in the pathogenesis of systemic lupus erythematosus

Neutrophil dysregulation is implicated in the pathogenesis of systemic lupus erythematosus (SLE). SLE is characterized by elevated levels of a pathogenic neutrophil subset known as low-density granulocytes (LDGs). The origin and phenotypic, functional, and pathogenic heterogeneity of LDGs remain to...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mistry, Pragnesh, Nakabo, Shuichiro, O’Neil, Liam, Goel, Rishi R., Jiang, Kan, Carmona-Rivera, Carmelo, Gupta, Sarthak, Chan, Diana W., Carlucci, Philip M., Wang, Xinghao, Naz, Faiza, Manna, Zerai, Dey, Amit, Mehta, Nehal N., Hasni, Sarfaraz, Dell’Orso, Stefania, Gutierrez-Cruz, Gustavo, Sun, Hong-Wei, Kaplan, Mariana J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6911190/
https://ncbi.nlm.nih.gov/pubmed/31754025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908576116
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