Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome

We report on patients with STAT3 loss-of-function (LOF) mutations who developed lupus-like autoimmunity. Immune dysregulation seen in STAT3 LOF patients suggests a susceptibility to systemic autoimmunity with important implications in monitoring and management of these patients.

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Goel, Rishi R., Nakabo, Shuichiro, Dizon, Brian L.P., Urban, Amanda, Waldman, Meryl, Howard, Lillian, Darnell, Dirk, Buhaya, Munir, Carmona-Rivera, Carmelo, Hasni, Sarfaraz, Kaplan, Mariana J., Freeman, Alexandra F., Gupta, Sarthak
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862417/
https://ncbi.nlm.nih.gov/pubmed/32768442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.07.024
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