Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variati...

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Bibliografski detalji
Izdano u:BMC Genomics
Glavni autori: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071748/
https://ncbi.nlm.nih.gov/pubmed/32171239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6626-9
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