Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variati...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:BMC Genomics
المؤلفون الرئيسيون: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2020
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071748/
https://ncbi.nlm.nih.gov/pubmed/32171239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6626-9
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