Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variati...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:BMC Genomics
Main Authors: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2020
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071748/
https://ncbi.nlm.nih.gov/pubmed/32171239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6626-9
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