Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variati...

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Publié dans:BMC Genomics
Auteurs principaux: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
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Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071748/
https://ncbi.nlm.nih.gov/pubmed/32171239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6626-9
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