Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells

Co-delivery of therapeutic agents and small interfering RNA (siRNA) can be achieved by a suitable nanovehicle. In this work, the solubility and bioavailability of curcumin (Cur) were enhanced by entrapment in a polyamidoamine (PAMAM) dendrimer, and a polyplex was formed by grafting Bcl-2 siRNA onto...

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Dettagli Bibliografici
Pubblicato in:Colloids Surf B Biointerfaces
Autori principali: Ghaffari, Maryam, Dehghan, Gholamreza, Baradaran, Behzad, Zarebkohan, Amir, Mansoori, Behzad, Soleymani, Jafar, Dolatabadi, Jafar Ezzati Nazhad, Hamblin, Michael R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071519/
https://ncbi.nlm.nih.gov/pubmed/31911391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.colsurfb.2019.110762
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