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Chronic, Twice-Daily Dosing of an NK2 Receptor Agonist [Lys(5),MeLeu(9),Nle(10)]-NKA(4-10), Produces Consistent Drug-Induced Micturition and Defecation in Chronic Spinal Rats

Acute administration of [Lys5,Me,Leu9,Nle10]-NKA(4-10) (LMN-NKA) produces contractions of the detrusor and rectum with voiding in intact and acutely spinal cord injured (SCI) rats. In the current study, the ability of LMN-NKA (10 μg/kg or 100 μg/kg, subcutaneous [SC], twice a day [bid]) or vehicle t...

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Detalhes bibliográficos
Publicado no:J Neurotrauma
Main Authors: Marson, Lesley, Piatt, Raymond Keast, Katofiasc, Mary A., Bobbitt, Carol, Thor, Karl B.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7071061/
https://ncbi.nlm.nih.gov/pubmed/31642371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2019.6676
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