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Pharmacodynamic evaluation of Lys(5), MeLeu(9), Nle(10)-NKA((4–10)) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats

PURPOSE: To determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK(2) receptor) agonist, Lys(5), MeLeu(9), Nle(10)-NKA((4–10)) (LMN-NKA). METHODS: Cystometry and colorectal pressure m...

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Publicat a:Naunyn Schmiedebergs Arch Pharmacol
Autors principals: Kullmann, F. Aura, Katofiasc, M., Thor, K.B., Marson, L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512890/
https://ncbi.nlm.nih.gov/pubmed/27889808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00210-016-1317-4
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