Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice

Aberrant NF-κB activation is a hallmark of most B-cell malignancies. Recurrent inactivating somatic mutations in the NFKBIE gene, which encodes IκBε, an inhibitor of NF-κB-inducible activity, are reported in several B-cell malignancies with highest frequencies in chronic lymphocytic leukemia and pri...

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Udgivet i:Blood Cancer J
Main Authors: Della-Valle, Veronique, Roos-Weil, Damien, Scourzic, Laurianne, Mouly, Enguerran, Aid, Zakia, Darwiche, Walaa, Lecluse, Yann, Damm, Frederik, Mémet, Sylvie, Mercher, Thomas, Aoufouchi, Said, Nguyen-Khac, Florence, Bernard, Olivier A., Ghamlouch, Hussein
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7070037/
https://ncbi.nlm.nih.gov/pubmed/32170099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-020-0305-6
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