Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

Voltage-gated ion channels feature voltage sensor domains (VSDs) that exist in three distinct conformations during activation: resting, intermediate, and activated. Experimental determination of the structure of a potassium channel VSD in the intermediate state has previously proven elusive. Here, w...

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Vydáno v:eLife
Hlavní autoři: Taylor, Keenan C, Kang, Po Wei, Hou, Panpan, Yang, Nien-Du, Kuenze, Georg, Smith, Jarrod A, Shi, Jingyi, Huang, Hui, White, Kelli McFarland, Peng, Dungeng, George, Alfred L, Meiler, Jens, McFeeters, Robert L, Cui, Jianmin, Sanders, Charles R
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Structural Biology and Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069725/
https://ncbi.nlm.nih.gov/pubmed/32096762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53901
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