Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGFβ1/Smad3 and Wnt/β-catenin pathways

INTRODUCTION: Lysyl hydroxylase 3 (LH3) is a collagen post-translational modifying enzyme; it is abnormally activated during the formation of collagen cross-links. iCRT3 is an inhibitor of both Wnt and β-catenin responsive transcription. We hypothesized that LH3 is regulated by TGFβ1/Smad3 signaling...

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Bibliographic Details
Published in:Arch Med Sci
Main Authors: Shao, Songjun, Fang, Haiyan, Duan, Lindi, Ye, Xianwei, Rao, Shanshan, Han, Jin, Li, Yumei, Yuan, Guohang, Liu, Weijia, Zhang, Xiangyan
Format: Artigo
Language:Inglês
Published: Termedia Publishing House 2019
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069430/
https://ncbi.nlm.nih.gov/pubmed/32190155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/aoms.2018.81357
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