Overexpression of BMP-7 reverses TGF-β1-induced epithelial-mesenchymal transition by attenuating the Wnt3/β-catenin and TGF-β1/Smad2/3 signaling pathways in HK-2 cells

Tubular epithelial cells undergoing epithelial-mesenchymal transition (EMT) is a crucial event in the progression of renal interstitial fibrosis (RIF). Bone morphogenetic protein-7 (BMP-7) has been reported to exhibit anti-fibrotic functions in various renal diseases. However, the function of BMP-7...

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Publicado en:Mol Med Rep
Autores principales: Song, Yan, Lv, Shasha, Wang, Fang, Liu, Xiaoli, Cheng, Jing, Liu, Shanshan, Wang, Xiaoying, Chen, Wei, Guan, Guangju, Liu, Gang, Peng, Changliang
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6947920/
https://ncbi.nlm.nih.gov/pubmed/31974602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2019.10875
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