Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination

BACKGROUND: Vulvar high-grade squamous intraepithelial lesion (vHSIL) is predominantly induced by high-risk human papilloma virus type 16 (HPV16). In two independent trials, therapeutic vaccination against the HPV16 E6 and E7 oncoproteins resulted in objective partial and complete responses (PRs/CRs...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Abdulrahman, Ziena, de Miranda, Noel, van Esch, Edith M G, de Vos van Steenwijk, Peggy J, Nijman, Hans W, J. P. Welters, Marij, van Poelgeest, Mariette I E, van der Burg, Sjoerd H
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Immunotherapy Biomarkers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069269/
https://ncbi.nlm.nih.gov/pubmed/32169871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000563
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