High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status

BACKGROUND: Vulvar squamous cell carcinoma (VSCC) has been suggested to consist of three subtypes; HPV-positive, HPV-negative mutated TP53 or HPV-negative TP53 wildtype, with different clinical courses. To analyze the immune infiltrate in these molecular subtypes and its impact on clinical outcome,...

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Publicat a:J Immunother Cancer
Autors principals: Kortekaas, Kim E., Santegoets, Saskia J., Abdulrahman, Ziena, van Ham, Vanessa J., van der Tol, Marij, Ehsan, Ilina, van Doorn, Helena C., Bosse, Tjalling, van Poelgeest, Mariëtte I. E., van der Burg, Sjoerd H.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724316/
https://ncbi.nlm.nih.gov/pubmed/31481117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0712-z
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