The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous transcriptional regulation is l...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Rodríguez-López, María, Gonzalez, Suam, Hillson, Olivia, Tunnacliffe, Edward, Codlin, Sandra, Tallada, Victor A., Bähler, Jürg, Rallis, Charalampos
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7068653/
https://ncbi.nlm.nih.gov/pubmed/32160533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.02.058
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