Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

Insulin resistance is associated with aging in mice and humans. We have previously shown that administration of recombinant GDF11 (rGDF11) to aged mice alters aging phenotypes in the brain, skeletal muscle, and heart. While the closely related protein GDF8 has a role in metabolism, limited data are...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Walker, Ryan G., Barrandon, Ornella, Poggioli, Tommaso, Dagdeviren, Sezin, Carroll, Shannon H., Mills, Melanie J., Mendello, Kourtney R., Gomez, Yanet, Loffredo, Francesco S., Pancoast, James R., Macias-Trevino, Claudio, Marts, Colin, LeClair, Katherine B., Noh, Hye-Lim, Kim, Taekyoon, Banks, Alexander S., Kim, Jason K., Cohen, David E., Wagers, Amy J., Melton, Douglas A., Lee, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067781/
https://ncbi.nlm.nih.gov/pubmed/32165710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61443-y
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