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Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

Mendelian randomization (MR) implemented through instrumental variables analysis is an increasingly popular causal inference tool used in genetic epidemiology. But it can have limitations for evaluating simultaneous causal relationships in complex data sets that include, for example, multiple geneti...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Howey, Richard, Shin, So-Youn, Relton, Caroline, Davey Smith, George, Cordell, Heather J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067488/
https://ncbi.nlm.nih.gov/pubmed/32119656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008198
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