Pharmacogenetic—Whole blood and intracellular pharmacokinetic—Pharmacodynamic (PG-PK(2)-PD) relationship of tacrolimus in liver transplant recipients

Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and intracellular exposures as well as the pharmacokinetic-pharmacodynamic relationship of TAC in both comp...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Tron, Camille, Woillard, Jean-Baptiste, Houssel-Debry, Pauline, David, Véronique, Jezequel, Caroline, Rayar, Michel, Balakirouchenane, David, Blanchet, Benoit, Debord, Jean, Petitcollin, Antoine, Roussel, Mickaël, Verdier, Marie-Clémence, Bellissant, Eric, Lemaitre, Florian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7067455/
https://ncbi.nlm.nih.gov/pubmed/32163483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0230195
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