PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

Bone marrow mesenchymal stem cells (BMSCs) differentiation dysfunction is a common pathological phenotype of several prevalent metabolic and genetic bone diseases. Pyruvate kinase muscle isoenzyme 2 (PKM2) regulates the last step of glycolysis, and its role in BMSCs differentiation is still unknown....

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Bibliographic Details
Published in:Aging (Albany NY)
Main Authors: Guo, Jiachao, Ren, Ranyue, Yao, Xudong, Ye, Yaping, Sun, Kai, Lin, Jiamin, Wang, Genchun, Guo, Fengjing, Xiao, Jun, Xu, Tao
Format: Artigo
Language:Inglês
Published: Impact Journals 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066892/
https://ncbi.nlm.nih.gov/pubmed/32096765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102866
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