Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways

Iron overload has been reported to contribute to bone marrow mesenchymal stem cells (BMSCs) damage, but the precise mechanism still remains elusive. Icariin, a major bioactive monomer belonging to flavonoid glucosides isolated from Herba Epimedii, has been shown to protect cells from oxidative stres...

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Détails bibliographiques
Publié dans:Front Pharmacol
Auteurs principaux: Yao, Xudong, Jing, Xingzhi, Guo, Jiachao, Sun, Kai, Deng, Yi, Zhang, Yong, Guo, Fengjing, Ye, Yaping
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403125/
https://ncbi.nlm.nih.gov/pubmed/30873034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00163
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