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BACE2 degradation is mediated by both the proteasome and lysosome pathways
BACKGROUND: Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving enzyme 1 (BACE1) is the major β-secretase contributing to Aβ generation. β-site A...
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| Publicado no: | BMC Mol Cell Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7066761/ https://ncbi.nlm.nih.gov/pubmed/32160867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00260-7 |
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