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Chemical modification of melphalan as a key to improving treatment of haematological malignancies

Chemical modification of known, effective drugs is one method to improve chemotherapy. Thus, the object of this study was to generate melphalan derivatives with improved cytotoxic activity in human cancer cells (RPMI8226, HL60 and THP1). Several melphalan derivatives were synthesised, modified in th...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gajek, Arkadiusz, Poczta, Anastazja, Łukawska, Małgorzata, Cecuda- Adamczewska, Violetta, Tobiasz, Joanna, Marczak, Agnieszka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066245/
https://ncbi.nlm.nih.gov/pubmed/32161295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61436-x
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