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High risk of breast cancer in women with biallelic pathogenic variants in CHEK2

PURPOSE: Compared to breast cancer risk genes such as BRCA2, ATM, PALB2, and NBN, no defined phenotype is currently associated with biallelic pathogenic variants (PVs) in CHEK2. This study compared the prevalence of breast and other cancers in women with monoallelic and biallelic CHEK2 PVs. METHODS:...

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Publicat a:Breast Cancer Res Treat
Autors principals: Rainville, Irene, Hatcher, Shanell, Rosenthal, Eric, Larson, Katie, Bernhisel, Ryan, Meek, Stephanie, Gorringe, Heidi, Mundt, Erin, Manley, Susan
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066089/
https://ncbi.nlm.nih.gov/pubmed/31993860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-020-05543-3
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