p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-ind...

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Sparad:
Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Che, Hui, Li, Jie, Li, You, Ma, Cheng, Liu, Huan, Qin, Jingyi, Dong, Jianghui, Zhang, Zhen, Xian, Cory J, Miao, Dengshun, Wang, Liping, Ren, Yongxin
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Human Biology and Medicine
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065909/
https://ncbi.nlm.nih.gov/pubmed/32125276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52570
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