p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression levels were found to be positively correlated with the severity of human IVDD. In a mouse tail suspension (TS)-ind...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Che, Hui, Li, Jie, Li, You, Ma, Cheng, Liu, Huan, Qin, Jingyi, Dong, Jianghui, Zhang, Zhen, Xian, Cory J, Miao, Dengshun, Wang, Liping, Ren, Yongxin
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065909/
https://ncbi.nlm.nih.gov/pubmed/32125276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.52570
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