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Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase from Leishmania major

[Image: see text] Class I fumarate hydratases (FHs) are central metabolic enzymes that use a [4Fe-4S] cluster to catalyze the reversible conversion of fumarate to S-malate. The parasite Leishmania major, which is responsible for leishmaniasis, expresses two class I FH isoforms: mitochondrial LmFH-1...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Feliciano, Patricia R., Drennan, Catherine L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065722/
https://ncbi.nlm.nih.gov/pubmed/31743022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00923
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