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Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate

[Image: see text] Leishmaniases affect the poorest people on earth and have no effective drug therapy. Here, we present the crystal structure of the mitochondrial isoform of class I fumarate hydratase (FH) from Leishmania major and compare it to the previously determined cytosolic Leishmania major i...

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Publicat a:ACS Chem Biol
Autors principals: Feliciano, Patricia R., Drennan, Catherine L., Nonato, Maria Cristina
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380369/
https://ncbi.nlm.nih.gov/pubmed/30645090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00972
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