mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo

Introduction: Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current available therapies reduces inflammation in SpA, however, treatment of the bone pathology in SpA remains an unmet clinical need. Ac...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Chen, Sijia, van Tok, Melissa N., Knaup, Véronique L., Kraal, Lianne, Pots, Désiree, Bartels, Lina, Gravallese, Ellen M., Taurog, Joel D., van de Sande, Marleen, van Duivenvoorde, Leonie M., Baeten, Dominique L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065603/
https://ncbi.nlm.nih.gov/pubmed/32194539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02344
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