FTY720 Exerts Anti-Glioma Effects by Regulating the Glioma Microenvironment Through Increased CXCR4 Internalization by Glioma-Associated Microglia

Background: Glioblastoma (GBM) is one of the most malignant and aggressive primary brain tumors. The incurability of glioblastoma is heavily influenced by the glioma microenvironment. FTY720, a potent immunosuppressant, has been reported to exert anti-tumor effects in glioblastoma. However, the impa...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Guo, Xu-Dong, Ji, Juan, Xue, Teng-Fei, Sun, Yu-Qin, Guo, Ruo-Bing, Cheng, Hong, Sun, Xiu-Lan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065571/
https://ncbi.nlm.nih.gov/pubmed/32194542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.00178
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