FTY720 Exerts Anti-Glioma Effects by Regulating the Glioma Microenvironment Through Increased CXCR4 Internalization by Glioma-Associated Microglia

Background: Glioblastoma (GBM) is one of the most malignant and aggressive primary brain tumors. The incurability of glioblastoma is heavily influenced by the glioma microenvironment. FTY720, a potent immunosuppressant, has been reported to exert anti-tumor effects in glioblastoma. However, the impa...

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Detalhes bibliográficos
Main Authors: Xu-Dong Guo, Juan Ji, Teng-Fei Xue, Yu-Qin Sun, Ruo-Bing Guo, Hong Cheng, Xiu-Lan Sun
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-03-01
Colecção:Frontiers in Immunology
Assuntos:
FTY720
glioma microenvironment
glioma-associated microglia and macrophages
chemoattraction
polarization
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.00178/full
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