Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica

The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella enterica ridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5′-phosphate (PLP)-dependent enzyme...

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Argitaratua izan da:mSystems
Egile Nagusiak: Borchert, Andrew J., Gouveia, Goncalo J., Edison, Arthur S., Downs, Diana M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065518/
https://ncbi.nlm.nih.gov/pubmed/32156800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00843-19
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