Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica

The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella enterica ridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5′-phosphate (PLP)-dependent enzyme...

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Detaylı Bibliyografya
Yayımlandı:mSystems
Asıl Yazarlar: Borchert, Andrew J., Gouveia, Goncalo J., Edison, Arthur S., Downs, Diana M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7065518/
https://ncbi.nlm.nih.gov/pubmed/32156800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00843-19
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