Integrated Metabolomics and Transcriptomics Suggest the Global Metabolic Response to 2-Aminoacrylate Stress in Salmonella enterica

In Salmonella enterica, 2-aminoacrylate (2AA) is a reactive enamine intermediate generated during a number of biochemical reactions. When the 2-iminobutanoate/2-iminopropanoate deaminase (RidA; EC: 3.5.99.10) is eliminated, 2AA accumulates and inhibits the activity of multiple pyridoxal 5’-phosphate...

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Publicat a:Metabolites
Autors principals: Borchert, Andrew J., Walejko, Jacquelyn M., Guennec, Adrien Le, Ernst, Dustin C., Edison, Arthur S., Downs, Diana M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023182/
https://ncbi.nlm.nih.gov/pubmed/31878179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo10010012
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