Maternal Broadly Neutralizing Antibodies Can Select for Neutralization-Resistant, Infant-Transmitted/Founder HIV Variants

Each year, >180,000 infants become infected via mother-to-child transmission (MTCT) of HIV despite the availability of effective maternal antiretroviral treatments, underlining the need for a maternal HIV vaccine. We characterized 224 maternal HIV envelope (Env)-specific IgG monoclonal antibodies...

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Publicado en:mBio
Main Authors: Martinez, David R., Tu, Joshua J., Kumar, Amit, Mangold, Jesse F., Mangan, Riley J., Goswami, Ria, Giorgi, Elena E., Chen, Juilin, Mengual, Michael, Douglas, Ayooluwa O., Heimsath, Holly, Saunders, Kevin O., Nicely, Nathan I., Eudailey, Joshua, Hernandez, Giovanna, Morgan-Asiedu, Papa Kwadwo, Wiehe, Kevin, Haynes, Barton F., Moody, M. Anthony, LaBranche, Celia, Montefiori, David C., Gao, Feng, Permar, Sallie R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064758/
https://ncbi.nlm.nih.gov/pubmed/32156815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00176-20
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