Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important challenges. Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor...

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Publicado no:Nat Commun
Main Authors: Chong, Chloe, Müller, Markus, Pak, HuiSong, Harnett, Dermot, Huber, Florian, Grun, Delphine, Leleu, Marion, Auger, Aymeric, Arnaud, Marion, Stevenson, Brian J., Michaux, Justine, Bilic, Ilija, Hirsekorn, Antje, Calviello, Lorenzo, Simó-Riudalbas, Laia, Planet, Evarist, Lubiński, Jan, Bryśkiewicz, Marta, Wiznerowicz, Maciej, Xenarios, Ioannis, Zhang, Lin, Trono, Didier, Harari, Alexandre, Ohler, Uwe, Coukos, George, Bassani-Sternberg, Michal
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064602/
https://ncbi.nlm.nih.gov/pubmed/32157095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14968-9
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