High-throughput and Sensitive Immunopeptidomics Platform Reveals Profound Interferonγ-Mediated Remodeling of the Human Leukocyte Antigen (HLA) Ligandome

Comprehensive knowledge of the human leukocyte antigen (HLA) class-I and class-II peptides presented to T-cells is crucial for designing innovative therapeutics against cancer and other diseases. However methodologies for their purification for mass-spectrometry analysis have been a major limitation...

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Vydáno v:Mol Cell Proteomics
Hlavní autoři: Chong, Chloe, Marino, Fabio, Pak, HuiSong, Racle, Julien, Daniel, Roy T., Müller, Markus, Gfeller, David, Coukos, George, Bassani-Sternberg, Michal
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2018
Témata:
Technological Innovation and Resources
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836376/
https://ncbi.nlm.nih.gov/pubmed/29242379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.TIR117.000383
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