Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development

Emerging drug resistance and high-attrition rates in early and late stage drug development necessitate accelerated development of antimalarial compounds. However, systematic and meaningful translation of drug efficacy and host-parasite dynamics between preclinical testing stages is missing. We devel...

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Vydáno v:Sci Rep
Hlavní autoři: Burgert, Lydia, Rottmann, Matthias, Wittlin, Sergio, Gobeau, Nathalie, Krause, Andreas, Dingemanse, Jasper, Möhrle, Jörg J., Penny, Melissa A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064600/
https://ncbi.nlm.nih.gov/pubmed/32157151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61304-8
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