Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment

Pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating disease where no treatment exists, involves the compartmentalization of the nuclear protein TDP-43 (TAR DNA-binding protein 43) in the cytoplasm which is promoted by its aberrant phosphorylation and others posttranslational modificat...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Martínez-González, Loreto, Rodríguez-Cueto, Carmen, Cabezudo, Diego, Bartolomé, Fernando, Andrés-Benito, Pol, Ferrer, Isidro, Gil, Carmen, Martín-Requero, Ángeles, Fernández-Ruiz, Javier, Martínez, Ana, de Lago, Eva
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7064575/
https://ncbi.nlm.nih.gov/pubmed/32157143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-61265-y
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