Efficacy of Evolocumab in Monogenic vs Polygenic Hypercholesterolemia

BACKGROUND: Inhibitors of proprotein convertase subtilisin kexin 9 are indicated in Canada for treatment of patients with familial hypercholesterolemia (FH). Classically, FH is considered to be a monogenic condition caused by rare pathogenic mutations; however, some patients have hypercholesterolemi...

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Bibliographic Details
Published in:CJC Open
Main Authors: Lee, Timothy, Iacocca, Michael A., Ban, Matthew R., Hegele, Robert A.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063626/
https://ncbi.nlm.nih.gov/pubmed/32159093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cjco.2019.02.005
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