Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia

BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mut...

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Detalhes bibliográficos
Publicado no:Atherosclerosis
Main Authors: Sharifi, Mahtab, Higginson, Elizabeth, Bos, Sven, Gallivan, Angela, Harvey, Darren, Li, Ka Wah, Abeysekera, Amali, Haddon, Angela, Ashby, Helen, Shipman, Kate E., Cooper, Jackie A., Futema, Marta, Roeters van Lennep, Jeanine E., Sijbrands, Eric J.G., Labib, Mourad, Nair, Devaki, Humphries, Steve E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567405/
https://ncbi.nlm.nih.gov/pubmed/28549500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2017.05.015
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