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Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We found that short-term induction of oncogenic Ras(V12) activates downstream mitogen-act...
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| Publicado no: | Dev Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7063569/ https://ncbi.nlm.nih.gov/pubmed/32032547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.01.004 |
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