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Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement
To divide in a tissue, both normal and cancer cells become spherical and mechanically stiffen as they enter mitosis. We investigated the effect of oncogene activation on this process in normal epithelial cells. We found that short-term induction of oncogenic Ras(V12) activates downstream mitogen-act...
Gorde:
| Argitaratua izan da: | Dev Cell |
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| Egile Nagusiak: | , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Cell Press
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7063569/ https://ncbi.nlm.nih.gov/pubmed/32032547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.01.004 |
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