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The Hydrophobic Patch Directs Cyclin B to Centrosomes to Promote Global CDK Phosphorylation at Mitosis

The cyclin-dependent kinases (CDKs) are the major cell-cycle regulators that phosphorylate hundreds of substrates, controlling the onset of S phase and M phase [1, 2, 3]. However, the patterns of substrate phosphorylation increase are not uniform, as different substrates become phosphorylated at dif...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Basu, Souradeep, Roberts, Emma L., Jones, Andrew W., Swaffer, Matthew P., Snijders, Ambrosius P., Nurse, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7063568/
https://ncbi.nlm.nih.gov/pubmed/32084401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.12.053
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