Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor–Dependent and –Independent Mechanisms over a Wide Range in Serum Potassium

BACKGROUND: Aldosterone activates the intercalated cell mineralocorticoid receptor, which is enhanced with hypokalemia. Whether this receptor directly regulates the intercalated cell chloride/bicarbonate exchanger pendrin is unclear, as are potassium’s role in this response and the receptor’s effect...

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Udgivet i:J Am Soc Nephrol
Main Authors: Pham, Truyen D., Verlander, Jill W., Wang, Yanhua, Romero, Cesar A., Yue, Qiang, Chen, Chao, Thumova, Monika, Eaton, Douglas C., Lazo-Fernandez, Yoskaly, Wall, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2020
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7062219/
https://ncbi.nlm.nih.gov/pubmed/32054691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019050551
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